MASTER'S THESIS

MASTER’S THESIS

.NeuroRestore is a research and innovation center spanning EPFL, CHUV and UNIL that develops and applies bioengineering strategies involving neurosurgical interventions to restore neurological functions. We integrate implantable neurotechnologies and innovative treatments resulting from rigorous preclinical studies that have been conducted during the last 15 years in rodent and non-human primate models. These developments have led to breakthroughs for the treatment of paraplegia, tetraplegia, Parkinson’s disease, stroke, and traumatic brain injuries.

Development of algorithms to optimize adaptive Deep Brain Stimulation parameters and control policies to alleviate locomotor deficits in people with Parkinson’s disease

The Position

.NeuroRestore is offering a Master’s thesis position to work on the development of adaptive deep-brain stimulation (DBS) therapies to alleviate locomotor deficits in patients with Parkinson’s Disease. 

The candidate’s main duties include:

  • • Analyzing multimodal clinical data (LFP and EMG) to assess neural modulations during locomotion and how they are affected by different therapy conditions.

    • Developing a processing pipeline for optimizing patient-specific adaptive DBS parameters to use in real time.

    • Contributing to the acquisition of multimodal clinical data (LFP, EMG, IMU, and video) from participants with Parkinson’s Disease.

The candidate should have:

Enrolled in an engineering or computer sciences master’s program from an accredited institution 

  • Strong signal processing skills

  • Experience with MATLAB and preferably with Git for collaborative development and code management

  • Strong attitude for teamwork and problem-solving

  • Outstanding adaptability and rapid learning capabilities

  • Demonstrated independence and a proactive approach in tasks

  • Excellent verbal and written communication skills

  • Fluent in English and preferably good in French

The qualified candidate will benefit from joining a dynamic and multidisciplinary group working at the interface of neurorehabilitation science, regulatory, medical science, engineering, and prosthetics. They will collaborate with EPFL academic labs, CHUV clinicians and vibrant medical high-tech companies. The candidate will have the opportunity to work at the interface between academia, industry, and the clinic with collaborators from different backgrounds and cultures, including worldwide scientific experts in rehabilitation and neurotechnology. The candidate will get credits for the internship.

Location: The candidate will work at our .NeuroRestore offices at CHUV campus, Lausanne.

Contact: Application including a CV and a short motivation letter should be sent to valeria.deseta@epfl.ch and camille.varescon@chuv.ch

Matthieu Gautier